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Radiotherapy, also called radiation therapy, is the treatment of cancer and other diseases with ionizing radiation.” Ionizing radiation deposits energy that destroys cells in the area being treated by damaging their genetic material, making it impossible for these cells to continue to grow. Although radiations damage both cancer cells and normal cells, but the normal cells are able to repair themselves and function properly again.
The aim of radiation therapy is to spare normal tissues (such as skin or organs which radiation must pass through in order to treat the tumor) and cause as much damage as it can to the cancerous cells. For this purpose radiation beams are shaped and are aimed from several angles of exposure to intersect at the tumor, providing a much larger absorbed dose at the target than in the surrounding healthy tissue.
It is also common to combine radiation therapy with surgery, chemotherapy, hormone therapy, immunotherapy or some mixture of the four.
Usually there are two types of radiation therapy. The first, and most common type is external beam radiotherapy, and the second one is known as internal radiotherapy, or brachytherapy. The external beam radiotherapy is carried out using x-rays, gamma rays, and particle beams, including electron  beam, or proton beams. This is always the choice of physicist to select the most appropriate beam according to the need of the treatment. Physicists must know the detail characteristics of all the beams used for such treatment, including their attenuation properties, percentage depth dose, and other Dosimetric parameters.
Usually Cobalt-60 and linear accelerators are used for external beam radiotherapy. In cobalt-60 (which is most common in various cancer hospitals in Pakistan), gamma rays are used to treat the malignant tumors. These rays give a gamma beam of average energy 1.25 MeV. However, the problem with these radiation sources is that there is a continuous decay ( and half-life of Cobalt-60 is 5.26 years). This work aims to evaluate the effect of this decay and then to determine some mechanism to calculate the radiation dose after incorporating that decay effect.



The Cobalt-60 tele-therapy units are installed in many hospitals of Pakistan Atomic Energy Commission. In this project, the commissioning data will be obtained from Bahawalpur Institute of Nuclear Medicine & Oncology (BINO), Bahawalpur, and from any other cancer hospital if needed. The data will later be analyzed with various software’s, and the some conclusion will ultimately be made.

Expected Outcome

Once the effect of decay on the treatment is known, it will be helpful to modify the dose calculations, and hence will help to increase the accuracy of treatment. The objective of radiotherapy treatment is always to deliver maximum dose to the target volume, and to spare the surrounding normal tissues as much as possible. The incorporation of these results, will aid to achieve the desired dose distribution in target tumors and to achieve the true objectives of the treatment.

Synopsis For M.Phil


Synopsis For M.Phil
Synopsis for M.Phil, format of synopsis, thesis format, synopsis format for Gomal University D.I Khan.




SYNOPSIS FOR M-PHIL STUDIES ENTITLED


Modification in Dose Distribution for Radiotherapy Treatment Planning


Research Proposal



 
 
















Submitted By
X.Y.Z
M. Phil Scholar
Session 2014-18

                                                           






PHYSICS DEPARTMENT
GOMAL UNIVERSITY, D. I. KHAN


Modification in Dose Distribution for Radiotherapy Treatment Planning


Synopsis of proposed thesis research submitted in partial fulfillment of the requirements for the degree of M. Phil.





Submitted By

X.Y.Z


Approved by the Supervisory Committee
(Name and signature)



1. Prof. Dr. A.B.C                               Supervisor/Chairperson ----------------------------
2. Prof. Dr. X.Y.Z                               Co-Supervisor ---------------------------------------
    Islamia University Bahawalpur











Contents
1. Introduction. 4
2. Literature Review.. 4
3. Aims and Objective. 6
4. Sample. 6
5. Methodology. 7
6. Materials. 7
7. Significance. 7
8. References

1.       Introduction


Radiation therapy is used for cancer treatment by using high doses of radiation to kill cancer cells and stop them from spreading. At low doses, radiation is used as an x-ray to see inside your body and take pictures, such as x-rays of your teeth or broken bones. Radiation used in cancer treatment works in much the same way, except that it is given at higher doses.
Radiation therapy can be external or internal. Sometimes people get both forms of radiation therapy [1].
Many people with cancer need radiation therapy. In fact, more than half of people with cancer get radiation therapy. Sometimes, radiation therapy is the only kind of cancer treatment people need.
External beam radiation therapy utilizes a linear accelerator to direct highenergy photons andelectrons at the cancer. To minimize side effects, the treatmentsare usually given on week days for a specific number of weeks which are calculated by the radiationoncologist, physicist, and dosimetrist.
Using treatment planning software, the treatment team controls the size and shape of the beam and how it is aimed at the patient’s body, to effectively treat the tumorwhile avoiding the surrounding normal tissue. Several types of external beam therapy have been discussed. The radiation oncologist will recommend one of thesetreatments if it is medically indicated and suitable for patients care.

2. Literature Review

3. Aims and Objective

4. Sample



Statement of Problem:

To effectively evaluate and implement treatment plans, accurate calculation of radiation dose distribution in three dimensions using 3-dimensional anatomic information is essential [39]. Radiation therapy treatment always focuses to shape the three dimensional dose distribution capable to compactly surround the tumor volume. This implies that the requirements for the spatial accuracy of the relationship between dose and volumes of interest are steadily increasing. The complex anatomy of the patient and the complex shape and intensity distribution of the beam in target volume, make this task not easy to accomplish. Advancement in Radiation therapy treatment and treatment planning leads to provide best possible outcome, but this can only be possible if there is fast and accurate dose calculation engine available. This calculation system is very important component of the treatment planning system.


5. Methodology


The Radiotherapy Machines, such as linear accelerator , and their related Treatment Planing Systems, will be used in ShaukatKhanum Cancer Hospital & Research Center Lahore. The three dimensional conformal radiotherapy, intensity modulated radiation therapy, and image guided radiation therapy , treatment plans will be made and evaluated. Various degress of freedom will be utilized to achieve the best possible dose distribution, and resultantly for the best possible treatment outcome.

6. Materials


7. Significance


Expected Outcome:
                
The evaluation of treatment plans will help to achieve the optimum and best possible treatment option for cancer patients undergoing radiotherapy. The dose distribution calculation systems will be analyzed and comparative analysis will help to select most appropriate set of parameters.

8. References


Halperin EC, Perez CA, Brady LW (Eds). Principles and Practice of Radiation
Oncology, Fifth Ed. Philadelphia: Lippincott Williams & Wilkins; 2008.

[2].      Mundt AJ, Roeske JC, Chung TD, Weichselbaum RR. Radiation oncology. In: Kufe DW, Bast RC, Hait WN, et al, eds. Cancer Medicine. 7th ed. Hamilton, Ontario. BC: Decker Inc; 2006:517-536.

[3].      Halperin EC. Particle therapy and treatment of cancer. Lancet Oncol. 2006;7:676-685.

[4].      Principles of Radiation Therapy Michael J. Gazda, MS, and Lawrence R. Coia, MD

[5].      American Society for Therapeutic Radiology and Oncology
(Online: http://www.astro.org)

[6].      American Cancer Society
(Online: http://www.cancer.org)

[7].      National Cancer Institute. FactSheet: Radiation Therapy for Cancer. Accessed at
www.cancer.gov/cancertopics/factsheet/Therapy/radiation.

[8].      INTERNATIONAL ELECTROTECHNICAL COMMISSION, Medical Electrical
Equipment: Particular Requirements for the Safety of Electron Accelerators in the
Range 1 MeV to 50 MeV, Rep. 60601-2-1, IEC, Geneva (1998).
[9].      KARZMARK, C.J., NUNAN, C.S., TANABE, E., Medical Electron Accelerators,
McGraw-Hill, New York (1993).

[10].    GREENE, D., WILLIAMS, P.C., Linear Accelerators for Radiation Therapy, Institute
of Physics Publishing, Bristol (1997).

[11].    PODGORSAK, E.B., METCALFE, P., VAN DYK, J., “Medical accelerators”, The
Modern Technology in Radiation Oncology: A Compendium for Medical Physicists and Radiation Oncologists (VAN DYK, J., Ed.), Medical Physics Publishing, Madison, WI (1999) 349–435.

[12].    AMERICAN ASSOCIATION OF PHYSICISTS IN MEDICINE, Medical accelerator
safety considerations: Report of AAPM Radiation Therapy Committee Task Group
No. 35, Med. Phys. 20 (1993) 1261–1275.

[13].    J. Rosenman, E. L. Chaney, S. Sailer, G. W. Sherouse, and J. E. Tepper, "Recent advances in radiotherapy treatment planning," Cancer Invest, vol. 9, pp. 465-81, 1991.

[14].    “Development and Implementation of Conformal Radiotherapy in the United Kingdom”, The Royal College of Radiologists, London; RCP Ref BFCO (02)2; June 2002.

[15].    F.M. Khan . “Physics of Radiation Therapy”. Lippincott, Williams & Wilkins, USA, 2003.


[16].    Computerized Treatment Planning Systems For External Photon Beam Radiotherapy by M.D.C. EVANS ,Department of Medical Physics,McGill University Health Centre, Montreal, Quebec, Canada,2005